GenAge entry for NGFR (Homo sapiens)

Gene name (HAGRID: 37)

HGNC symbol: NGFR
Aliases: TNFRSF16; CD271; p75NTR
Common name: nerve growth factor receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: A receptor that can bind not only NGF but other neurotrophins, such as BDNF, NGFR mediates neural cell survival and is an important player in development. Results from mice suggest it may be related to brain ageing [337], though if and how it impacts on the human ageing process is not known.

Cytogenetic information

Cytogenetic band: 17q21-q22
Location: 49,495,293 bp to 49,515,020 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006886; intracellular protein transport
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007411; axon guidance
GO:0010977; negative regulation of neuron projection development
GO:0031293; membrane protein intracellular domain proteolysis
GO:0032496; response to lipopolysaccharide
GO:0032922; circadian regulation of gene expression
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0042127; regulation of cell proliferation

And 16 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009986; cell surface
GO:0043005; neuron projection

Function:

GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0004888; transmembrane signaling receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0017137; Rab GTPase binding
GO:0031625; ubiquitin protein ligase binding
GO:0048406; nerve growth factor binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, NGF, NGFR, H2AFX, CDKN1A, IKBKB, SQSTM1
STRING interaction network

Retrieve sequences for NGFR

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: uncharacterized_F1R8
Mus musculus: Ngfr
Rattus norvegicus: Ngfr

Selected references

[492] Bruce et al. (1996) "Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors." Nat. Med. 2(7):788-794 (PubMed)
[1190] Toran-Allerand et al. (1992) "Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain." Proc. Natl. Acad. Sci. U.S.A. 89(10):4668-4672 (PubMed)
[337] Alberch et al. (1991) "Involvement of nerve growth factor and its receptor in the regulation of the cholinergic function in aged rats." J. Neurochem. 57(5):1483-1487 (PubMed)
[334] Byers et al. (1990) "Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity." Development 109(2):461-471 (PubMed)
[335] Markram and Segal (1990) "Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat." Neurobiol. Aging 11(4):481-484 (PubMed)