GenAge entry for PEX5 (Homo sapiens)
Gene name (HAGRID: 58)
- HGNC symbol
- PEX5
- Aliases
- PTS1R; PXR1
- Common name
- peroxisomal biogenesis factor 5
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
A peroxisome receptor, PEX5 has been associated with genes and pathways previously related to ageing, such as ATM [994]. An involvement in cellular senescence has also been suggested [402]. Nonetheless, a direct role of PEX5 in human ageing has not been demonstrated.
Cytogenetic information
- Cytogenetic band
- 12p13.31
- Location
- 7,190,362 bp to 7,211,483 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0016558; protein import into peroxisome matrix
GO:0016560; protein import into peroxisome matrix, docking
GO:0045046; protein import into peroxisome membrane
GO:1901094; negative regulation of protein homotetramerization
Cellular component: GO:0005737; cytoplasm
GO:0005777; peroxisome
GO:0005778; peroxisomal membrane
GO:0016020; membrane
GO:0043234; protein complex
Hide GO termsFunction: GO:0000268; peroxisome targeting sequence binding
GO:0005052; peroxisome matrix targeting signal-1 binding
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0031267; small GTPase binding
GO:0047485; protein N-terminus binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- ATM, BRCA1, CAT, SIRT3, SQSTM1
- STRING interaction network
