GenAge entry for CAT (Homo sapiens)

Gene name (HAGRID: 107)

HGNC symbol: CAT
Aliases
Common name: catalase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. These mutants are also more resistant to age-related skeletal muscle dysfunction and exhibit improved voluntary exercise, increased muscle force, decreased intracellular Ca(2+) leak and increased sarcoplasmic reticulum Ca(2+) load [3638]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Cytogenetic information

Cytogenetic band: 11p13
Location: 34,438,925 bp to 34,472,060 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0001649; osteoblast differentiation
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0007568; aging
GO:0008203; cholesterol metabolic process
GO:0009060; aerobic respiration
GO:0009642; response to light intensity
GO:0009650; UV protection

And 28 more GO terms

Cellular component:	GO:0005615; extracellular space GO:0005739; mitochondrion GO:0005758; mitochondrial intermembrane space GO:0005764; lysosome GO:0005777; peroxisome GO:0005778; peroxisomal membrane GO:0005782; peroxisomal matrix GO:0005783; endoplasmic reticulum GO:0005794; Golgi apparatus GO:0005829; cytosol GO:0005886; plasma membrane
	And 5 more GO terms

Function:

GO:0004046; aminoacylase activity
GO:0004096; catalase activity
GO:0005102; receptor binding
GO:0016209; antioxidant activity
GO:0016684; oxidoreductase activity, acting on peroxide as acceptor
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050661; NADP binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PEX5, ABL1, CAT, SOD2, SOD1, APP, PRDX1, ESR1
STRING interaction network

Retrieve sequences for CAT

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ctl-3
Danio rerio: cat
Drosophila melanogaster: CG9314
Mus musculus: Cat
Rattus norvegicus: Cat
Saccharomyces cerevisiae: CTA1
Schizosaccharomyces pombe: cta1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Cat
A homolog of this gene for Saccharomyces cerevisiae is present as CTA1

LongevityMap

This gene is present as CAT