GenAge entry for RGN (Homo sapiens)

Gene name (HAGRID: 145)

HGNC symbol: RGN
Aliases: SMP30; RC
Common name: regucalcin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: RGN is mostly expressed in the liver, yet its functions remain obscure [723]. Its expression levels decline with age, and RGN has been linked to age-related changes in calcium signalling in the liver of rats [724]. RGN-null mice show susceptibility to TNF- and FAS-mediated apoptosis [182] and increased oxidative stress in brain [1634]. SMP30/SOD1-double knockout mice exhibit abnormal plasma lipid metabolism, hepatic lipid accumulation and premature death resulting from impaired VLDL secretion, both compared to wild type, SMP30-knockout and SOD1-knockout mice [3618]. A role for RGN in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: Xp11.3
Location: 47,078,355 bp to 47,093,314 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001822; kidney development
GO:0006469; negative regulation of protein kinase activity
GO:0006874; cellular calcium ion homeostasis
GO:0007283; spermatogenesis
GO:0007568; aging
GO:0010867; positive regulation of triglyceride biosynthetic process
GO:0010907; positive regulation of glucose metabolic process
GO:0010922; positive regulation of phosphatase activity
GO:0019853; L-ascorbic acid biosynthetic process
GO:0032515; negative regulation of phosphoprotein phosphatase activity
GO:0032781; positive regulation of ATPase activity
GO:0034260; negative regulation of GTPase activity
GO:0043066; negative regulation of apoptotic process
GO:0043547; positive regulation of GTPase activity
GO:0045019; negative regulation of nitric oxide biosynthetic process
GO:0045723; positive regulation of fatty acid biosynthetic process
GO:0050680; negative regulation of epithelial cell proliferation
GO:0050848; regulation of calcium-mediated signaling
GO:0051344; negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0097421; liver regeneration
GO:1901318; negative regulation of flagellated sperm motility
GO:1901671; positive regulation of superoxide dismutase activity
GO:1901896; positive regulation of calcium-transporting ATPase activity
GO:1902679; negative regulation of RNA biosynthetic process
GO:1903011; negative regulation of bone development
GO:1903052; positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903611; negative regulation of calcium-dependent ATPase activity
GO:1903625; negative regulation of DNA catabolic process
GO:1903629; positive regulation of dUTP diphosphatase activity
GO:1903634; negative regulation of leucine-tRNA ligase activity
GO:2000279; negative regulation of DNA biosynthetic process

Cellular component:

GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0004341; gluconolactonase activity
GO:0005509; calcium ion binding
GO:0008270; zinc ion binding
GO:0030234; enzyme regulator activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SOD1
STRING interaction network

Retrieve sequences for RGN

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: rgn
Drosophila melanogaster: regucalcin
Mus musculus: Rgn
Rattus norvegicus: Rgn
Saccharomyces cerevisiae: YBR053C