GenAge entry for TNF (Homo sapiens)

Gene name (HAGRID: 86)

HGNC symbol: TNF
Aliases: TNFSF2; DIF; TNF-alpha; TNFA
Common name: tumor necrosis factor

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems

Description

A cytokine involved in the immune response, TNF can induce cell death in some tumour cells. It can also induce cellular proliferation and differentiation [493].

TNF-deficient mice develop normally but are more susceptible to some infectious agents [493]. Other results from mice suggest that TNF may protect neurons by stimulating antioxidant pathways [492]. There is an association between TNF levels and age [715], though human polymorphisms in TNF have not been associated with longevity [221]. Although TNF may be associated with human age-related diseases, such as dementia [1168], more studies are necessary to establish what is TNF's involvement in human ageing.

Cytogenetic information

Cytogenetic band: 6p21.3
Location: 2,917,465 bp to 2,920,233 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000060; protein import into nucleus, translocation
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0000185; activation of MAPKKK activity
GO:0000187; activation of MAPK activity
GO:0001819; positive regulation of cytokine production
GO:0001934; positive regulation of protein phosphorylation
GO:0001937; negative regulation of endothelial cell proliferation
GO:0002439; chronic inflammatory response to antigenic stimulus
GO:0002740; negative regulation of cytokine secretion involved in immune response
GO:0002876; positive regulation of chronic inflammatory response to antigenic stimulus

And 107 more GO terms

Cellular component:

GO:0001891; phagocytic cup
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0009986; cell surface
GO:0045121; membrane raft
GO:0055037; recycling endosome

Function:

GO:0002020; protease binding
GO:0005125; cytokine activity
GO:0005164; tumor necrosis factor receptor binding
GO:0005515; protein binding
GO:0042802; identical protein binding
GO:0044212; transcription regulatory region DNA binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TNF, FAS, NFKBIA, CLU, CDC42, IKBKB
STRING interaction network

Retrieve sequences for TNF

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Tnf
Rattus norvegicus: Tnf

In other databases

LongevityMap

This gene is present as TNF