GenAge entry for S100B (Homo sapiens)

Gene name (HAGRID: 70)

HGNC symbol: S100B
Aliases: S100beta
Common name: S100 calcium binding protein B

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: S100B is mostly expressed in glial cells where it controls neuronal and glial cell proliferation. Its expression levels change with age [453] and in Alzheimer's disease [452]. Mice overexpressing the human S100B show pathological changes in their brains [1166]. S100B may thus be involved in neurodegenerative disorders, but there is no evidence at present that S100B plays a major role in human ageing.

Cytogenetic information

Cytogenetic band: 21q22.3
Location: 46,598,618 bp to 46,605,122 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007409; axonogenesis
GO:0007417; central nervous system development
GO:0007611; learning or memory
GO:0007613; memory
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0008360; regulation of cell shape
GO:0043065; positive regulation of apoptotic process
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087; innate immune response
GO:0048168; regulation of neuronal synaptic plasticity
GO:0048708; astrocyte differentiation
GO:0051384; response to glucocorticoid
GO:0051597; response to methylmercury
GO:0060291; long-term synaptic potentiation
GO:0071456; cellular response to hypoxia
GO:2001015; negative regulation of skeletal muscle cell differentiation

Cellular component:

GO:0001726; ruffle
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0043025; neuronal cell body
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0044548; S100 protein binding
GO:0048156; tau protein binding
GO:0048306; calcium-dependent protein binding
GO:0050786; RAGE receptor binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, S100B, MAPT, MDM2
STRING interaction network

Retrieve sequences for S100B

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: s100b
Mus musculus: S100b
Rattus norvegicus: S100b