GenAge entry for S100B (Homo sapiens)
Gene name (HAGRID: 70)
- HGNC symbol
- S100B
- Aliases
- S100beta
- Common name
- S100 calcium binding protein B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
S100B is mostly expressed in glial cells where it controls neuronal and glial cell proliferation. Its expression levels change with age [453] and in Alzheimer's disease [452]. Mice overexpressing the human S100B show pathological changes in their brains [1166]. S100B may thus be involved in neurodegenerative disorders, but there is no evidence at present that S100B plays a major role in human ageing.
Cytogenetic information
- Cytogenetic band
- 21q22.3
- Location
- 46,598,618 bp to 46,605,122 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007409; axonogenesis
GO:0007417; central nervous system development
GO:0007611; learning or memory
GO:0007613; memory
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0008360; regulation of cell shape
GO:0043065; positive regulation of apoptotic process
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087; innate immune response
GO:0048168; regulation of neuronal synaptic plasticity
And 7 more GO terms Cellular component: GO:0001726; ruffle
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0043025; neuronal cell body
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
Show all GO termsFunction: GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0044548; S100 protein binding
GO:0048156; tau protein binding
GO:0048306; calcium-dependent protein binding
GO:0050786; RAGE receptor binding
