GenAge entry for SOCS2 (Homo sapiens)

Gene name (HAGRID: 271)

HGNC symbol: SOCS2
Aliases: STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2
Common name: suppressor of cytokine signaling 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family and is a cytokine-inducible negative regulator of cytokine receptor signaling through the JAK/STAT pathway. The SOCS2 protein interacts with IGF1 and GH receptors IGF1R and GHR [2175] as a negative regulator of GH signaling [2177]. The lack of SOCS2 expression in the high-growth mouse increases plasma IGF1, and reduces plasma and pituitary GH1 levels. Mutant mice exhibited a reduced mean and maximal lifespan compared to wild type [2178]. SOCS2 is also involved in several types of cancer [2179].

Cytogenetic information

Cytogenetic band: 12q
Location: 93,569,822 bp to 93,576,745 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001558; regulation of cell growth
GO:0006469; negative regulation of protein kinase activity
GO:0007259; JAK-STAT cascade
GO:0009966; regulation of signal transduction
GO:0009967; positive regulation of signal transduction
GO:0016567; protein ubiquitination
GO:0019221; cytokine-mediated signaling pathway
GO:0032355; response to estradiol
GO:0032870; cellular response to hormone stimulus
GO:0043066; negative regulation of apoptotic process
GO:0046426; negative regulation of JAK-STAT cascade
GO:0046627; negative regulation of insulin receptor signaling pathway
GO:0060396; growth hormone receptor signaling pathway

Cellular component:

GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0004860; protein kinase inhibitor activity
GO:0005070; SH3/SH2 adaptor activity
GO:0005131; growth hormone receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0008269; JAK pathway signal transduction adaptor activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, IGF1R, EPOR, PTK2B, PTK2, BMI1
STRING interaction network

Retrieve sequences for SOCS2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: socs2
Mus musculus: Gm9847
Rattus norvegicus: Socs2

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Socs2

LongevityMap

This gene is present as SOCS2

CellAge gene expression

This gene is present as SOCS2