GenAge entry for SST (Homo sapiens)

Gene name (HAGRID: 53)

HGNC symbol: SST
Aliases: SMST
Common name: somatostatin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: Somatostatin is an important regulator of endocrine and nervous system function [386]. It inhibits the release of GH1 probably through GHRH [1568]. Because its levels change with age, it is likely that age-related changes are affected or affect SST [385], and a role for SST in Alzheimer's disease has also been proposed [1664].

Cytogenetic information

Cytogenetic band: 3q28
Location: 187,668,906 bp to 187,670,413 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006972; hyperosmotic response
GO:0007166; cell surface receptor signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007268; chemical synaptic transmission
GO:0007584; response to nutrient
GO:0007586; digestion
GO:0008285; negative regulation of cell proliferation
GO:0008628; hormone-mediated apoptotic signaling pathway
GO:0009408; response to heat
GO:0010447; response to acidic pH
GO:0030334; regulation of cell migration
GO:0042493; response to drug
GO:0043200; response to amino acid
GO:0048545; response to steroid hormone

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0043025; neuronal cell body

Function:

GO:0005179; hormone activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SSTR3
STRING interaction network

Retrieve sequences for SST

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: sst1.1
Mus musculus: Sst
Rattus norvegicus: Sst