GenAge entry for STAT5A (Homo sapiens)

Gene name (HAGRID: 23)

HGNC symbol: STAT5A
Aliases: MGF; STAT5
Common name: signal transducer and activator of transcription 5A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Like STAT5B, STAT5A is an important player in the activation of transcription and intracellular signalling. Mice with disrupted STAT5A and STAT5B, though short-lived due to numerous other deficiencies, exhibit phenotypes similar to those observed in GHR knockout mice in that they are 20%-40% smaller than controls with signs of disrupted GH1 functions such as lower IGF1 levels [1892]. Absence of Stat5 from pancreatic beta-cells in mice has no discernable impact on islet development and function in young animals, however, Stat5 appears to be an important component in beta-cell function in older mice [3666]. Its relation to other proteins that may be involved in ageing make STAT5A a promising subject of research in gerontology [266], though it is not known whether it plays a role in human ageing.

Cytogenetic information

Cytogenetic band: 17q11.2
Location: 42,287,547 bp to 42,311,942 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000255; allantoin metabolic process
GO:0001938; positive regulation of endothelial cell proliferation
GO:0006101; citrate metabolic process
GO:0006103; 2-oxoglutarate metabolic process
GO:0006105; succinate metabolic process
GO:0006107; oxaloacetate metabolic process
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006549; isoleucine metabolic process
GO:0006573; valine metabolic process
GO:0006600; creatine metabolic process
GO:0006631; fatty acid metabolic process
GO:0007259; JAK-STAT cascade
GO:0007595; lactation
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0019530; taurine metabolic process
GO:0038161; prolactin signaling pathway
GO:0040014; regulation of multicellular organism growth
GO:0043536; positive regulation of blood vessel endothelial cell migration
GO:0046449; creatinine metabolic process
GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway

Cellular component:

GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004713; protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, SHC1, PTPN11, STAT5A, PTPN1, EGFR, INSR, PDGFRB, EPOR, BRCA1, BRCA2, NFKB1, EP300, HDAC1, JAK2, ESR1, PPARG, SQSTM1
STRING interaction network

Retrieve sequences for STAT5A

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: stat5.2
Mus musculus: Stat5a
Rattus norvegicus: Stat5a

In other databases

CellAge

This gene is present as STAT5A