GenAge entry for JAK2 (Homo sapiens)

Gene name (HAGRID: 215)

HGNC symbol: JAK2
Aliases: JTK10
Common name: Janus kinase 2

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing

Description

JAK2 is a tyrosine kinase involved in cytokine receptor signalling. Disruption of JAK2 causes embryonic lethality due to the absence of definitive erythropoiesis [1175], however, knockdown or pharmacological inhibition of the JAK-STAT enhances satellite stem cell division potential, resulting in better muscle regeneration [3635].

Administrating JAK1/2 inhibitors to aged mice alleviates adipose and systemic inflammation, reduced frailty, and enhanced physical function. Upon JAK inhibition there was a reduction in inflammatory cytokines and chemokines. In addition, inhibition of the JAK pathway partially restored age-related decline in coordination [4344]. Inhibition of the JAK pathway using RNAi or JAK inhibitors in human cells suppresses the senescence associated secretory phenotype (SASP) [4344]. Its signalling functions and its association with a number of genes previously linked to ageing suggest JAK2 may play some role in ageing, even though a direct association of JAK2 with human ageing has not been established.

Cytogenetic information

Cytogenetic band: 9p24
Location: 4,985,245 bp to 5,128,183 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0002250; adaptive immune response
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928; movement of cell or subcellular component
GO:0007165; signal transduction
GO:0007167; enzyme linked receptor protein signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration

And 71 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005901; caveola
GO:0016363; nuclear matrix
GO:0031234; extrinsic component of cytoplasmic side of plasma membrane
GO:0031904; endosome lumen
GO:0045121; membrane raft

Function:

GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005131; growth hormone receptor binding
GO:0005143; interleukin-12 receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0019901; protein kinase binding

And 11 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, SHC1, PTPN11, STAT5B, STAT3, STAT5A, IRS1, PTPN1, EGFR, ERBB2, INSR, IL2RG, EPOR, BRCA1, HSP90AA1, EMD, GRB2, PTK2B, PTK2, FGFR1, MAP3K5, PIK3R1, HSPA8, JAK2, AGTR1
STRING interaction network

Retrieve sequences for JAK2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: jak2b
Mus musculus: Jak2
Rattus norvegicus: Jak2

In other databases

LongevityMap

This gene is present as JAK2

CellAge

This gene is present as JAK2