GenAge entry for TFAP2A (Homo sapiens)
Gene name (HAGRID: 190)
- HGNC symbol
- TFAP2A
- Aliases
- AP-2; TFAP2; AP2TF
- Common name
- transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
TFAP2A is a transcription factor involved in a variety of processes, including development and morphogenesis. Disruption of TFAP2A results in multiple developmental defects and death at birth [821]. Due to its association with WRN and other helicases [819], it is possible, though unproven, that TFAP2A plays some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 6p24
- Location
- 10,396,683 bp to 10,415,237 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001822; kidney development
GO:0003404; optic vesicle morphogenesis
GO:0003409; optic cup structural organization
GO:0006366; transcription from RNA polymerase II promoter
GO:0007605; sensory perception of sound
GO:0008285; negative regulation of cell proliferation
GO:0010628; positive regulation of gene expression
GO:0010842; retina layer formation
GO:0010944; negative regulation of transcription by competitive promoter binding
GO:0021559; trigeminal nerve development
GO:0021623; oculomotor nerve formation
GO:0030501; positive regulation of bone mineralization
GO:0035115; embryonic forelimb morphogenesis
GO:0042472; inner ear morphogenesis
GO:0043066; negative regulation of apoptotic process
GO:0043525; positive regulation of neuron apoptotic process
GO:0045595; regulation of cell differentiation
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048701; embryonic cranial skeleton morphogenesis
GO:0060021; palate development
GO:0060349; bone morphogenesis
GO:0061029; eyelid development in camera-type eye
GO:0070172; positive regulation of tooth mineralization
GO:0071281; cellular response to iron ion
GO:2000378; negative regulation of reactive oxygen species metabolic process
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0005813; centrosome
GO:0043231; intracellular membrane-bounded organelle
Hide GO termsFunction: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987; core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0043565; sequence-specific DNA binding
GO:0044212; transcription regulatory region DNA binding
GO:0046983; protein dimerization activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, MYC, BRCA1, NFKB1, UBE2I, EP300, XRCC5, XRCC6, RB1, RELA, SP1, JUN, MAX, CTNNB1, PPARG
- STRING interaction network
