GenAge entry for XRCC6 (Homo sapiens)
Gene name (HAGRID: 117)
- HGNC symbol
- XRCC6
- Aliases
- D22S731; D22S671; KU70; ML8; G22P1
- Common name
- X-ray repair complementing defective repair in Chinese hamster cells 6
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Like its counterpart XRCC5, XRCC6 is a helicase involved in DNA repair and chromatin remodelling [579]. Also called Ku70, XRCC6 has been linked to the telomeres [158], WRN [983], and other genes putatively regulating ageing. Mice with mutations in XRCC6 and XRCC5 exhibit signs of early ageing with low cancer levels, yet since XRCC5 mutants exhibit a similar phenotype the involvement of XRCC6 in the ageing phenotype is not clear in spite of some early signs of ageing in XRCC6 mutants [1906]. It is possible that XRCC6 is involved in ageing, though further results are necessary to determine whether it plays a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 22q13.2
- Location
- 41,621,163 bp to 41,664,048 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000723; telomere maintenance
GO:0006266; DNA ligation
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0032481; positive regulation of type I interferon production
GO:0032508; DNA duplex unwinding
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
And 8 more GO terms Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0016020; membrane
GO:0043564; Ku70:Ku80 complex
GO:0070419; nonhomologous end joining complex
Show all GO termsFunction: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0044212; transcription regulatory region DNA binding
GO:0044822; poly(A) RNA binding
GO:0044877; macromolecular complex binding
And 2 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, TERT, WRN, LMNA, MYC, PARP1, BRCA1, PIN1, CREBBP, RPA1, ABL1, PDPK1, CEBPA, EP300, HTT, EEF2, PRKDC, AR, XRCC5, PCNA, TERF2, XRCC6, BAX, EMD, HSF1, YWHAZ, SDHC, TFAP2A, MDM2, H2AFX, HOXB7, HOXC4, ESR1, CLU, SIRT6, PPARG, EPS8, SIRT7, TP53BP1, SIRT3
- STRING interaction network
