GenAge entry for TP63 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 234)

HGNC symbol: TP63
Aliases: p51; SHFM4; EEC3; p63; p73L; OFC8; KET; p73H; NBP; p53CP; TP73L; TP53L; TP53CP
Common name: tumor protein p63

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: TP63 is a homologue of TP53 that plays a role in development and oncogenesis by regulating proliferation and differentiation [1487]. This gene encodes several isoforms whose expression differs between tissues. TP63-null mice have major developmental defects [1489] and stem cells lacking p63 undergo a premature proliferative rundown in stratified epithelia [3669]. Heterozygous TP63 mice have a reduced lifespan (over 20% shorter than controls) and exhibit signs of premature ageing [1491]. Mutations in TP63 in humans have been associated with several disorders, including EEC which is characterized by ectrodactyly, ectodermal dysplasia, and facial clefts [1488]. Corneal dystrophy and premature menopause have also been associated with a mutation in TP63 [1942].

Cytogenetic information

Cytogenetic band: 3q28
Location: 189,631,427 bp to 189,897,279 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001302; replicative cell aging
GO:0001501; skeletal system development
GO:0001736; establishment of planar polarity
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002064; epithelial cell development
GO:0006338; chromatin remodeling
GO:0006366; transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219; Notch signaling pathway
GO:0007283; spermatogenesis
GO:0007499; ectoderm and mesoderm interaction
GO:0009954; proximal/distal pattern formation
GO:0010165; response to X-ray
GO:0010259; multicellular organism aging
GO:0010332; response to gamma radiation
GO:0010481; epidermal cell division
GO:0010482; regulation of epidermal cell division
GO:0010838; positive regulation of keratinocyte proliferation
GO:0030216; keratinocyte differentiation
GO:0030326; embryonic limb morphogenesis
GO:0030859; polarized epithelial cell differentiation
GO:0031069; hair follicle morphogenesis
GO:0031571; mitotic G1 DNA damage checkpoint
GO:0034644; cellular response to UV
GO:0036342; post-anal tail morphogenesis
GO:0042475; odontogenesis of dentin-containing tooth
GO:0042771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981; regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523; regulation of neuron apoptotic process
GO:0043589; skin morphogenesis
GO:0043616; keratinocyte proliferation
GO:0045617; negative regulation of keratinocyte differentiation
GO:0045669; positive regulation of osteoblast differentiation
GO:0045747; positive regulation of Notch signaling pathway
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048485; sympathetic nervous system development
GO:0048745; smooth muscle tissue development
GO:0048807; female genitalia morphogenesis
GO:0051289; protein homotetramerization
GO:0051402; neuron apoptotic process
GO:0060157; urinary bladder development
GO:0060197; cloacal septation
GO:0060513; prostatic bud formation
GO:0060529; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436; establishment of skin barrier
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901796; regulation of signal transduction by p53 class mediator
GO:2000271; positive regulation of fibroblast apoptotic process
GO:2000381; negative regulation of mesoderm development

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005791; rough endoplasmic reticulum
GO:0005829; cytosol
GO:0030425; dendrite

Function:

GO:0000989; transcription factor activity, transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0002039; p53 binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0042802; identical protein binding
GO:0043565; sequence-specific DNA binding
GO:0044212; transcription regulatory region DNA binding
GO:0046872; metal ion binding
GO:0050699; WW domain binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, BRCA1, VCP, NFKB1, UBE2I, CEBPB, STK11, EP300, PML, FAS, A2M, RELA, EEF1A1, MDM2, SUMO1, CDKN2A, TP63, CDKN1A, IKBKB
STRING interaction network

Retrieve sequences for TP63

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: tp63
Mus musculus: Tp63
Rattus norvegicus: Tp63

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Trp63

CellAge

This gene is present as TP63