GenAge entry for EEF1A1 (Homo sapiens)
Gene name (HAGRID: 189)
- HGNC symbol
- EEF1A1
- Aliases
- EE1A1; EF1A; EEF1A; LENG7
- Common name
- eukaryotic translation elongation factor 1 alpha 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity [814]. Whether EEF1A1 has any role in mammalian ageing has not been determined.
Cytogenetic information
- Cytogenetic band
- 6q14.1
- Location
- 73,515,750 bp to 73,521,032 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006414; translational elongation
GO:0071364; cellular response to epidermal growth factor stimulus
GO:1904714; regulation of chaperone-mediated autophagy
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005853; eukaryotic translation elongation factor 1 complex
GO:0016020; membrane
GO:0030864; cortical actin cytoskeleton
GO:0032587; ruffle membrane
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
And 2 more GO terms
Show all GO termsFunction: GO:0000049; tRNA binding
GO:0003746; translation elongation factor activity
GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0019901; protein kinase binding
GO:0044822; poly(A) RNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, EGFR, RPA1, HSP90AA1, EP300, GSK3B, EEF2, PCNA, FAS, RAD52, HSPA9, HSPA1A, MAPK14, EEF1A1, HSPA8, MDM2, H2AFX, TP63, SIRT6, CDKN1A, HTRA2, TRAP1
- STRING interaction network
