GenAge entry for TRPV1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 306)

HGNC symbol: TRPV1
Aliases: VR1
Common name: transient receptor potential cation channel subfamily V member 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Cytogenetic information

Cytogenetic band: 17p13.2
Location: 3,565,445 bp to 3,609,410 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001660; fever generation
GO:0001774; microglial cell activation
GO:0002024; diet induced thermogenesis
GO:0002790; peptide secretion
GO:0006629; lipid metabolic process
GO:0006810; transport
GO:0007166; cell surface receptor signaling pathway
GO:0007635; chemosensory behavior
GO:0014047; glutamate secretion
GO:0034605; cellular response to heat
GO:0043065; positive regulation of apoptotic process
GO:0043434; response to peptide hormone
GO:0045429; positive regulation of nitric oxide biosynthetic process
GO:0048266; behavioral response to pain
GO:0050954; sensory perception of mechanical stimulus
GO:0050955; thermoception
GO:0050960; detection of temperature stimulus involved in thermoception
GO:0050965; detection of temperature stimulus involved in sensory perception of pain
GO:0050968; detection of chemical stimulus involved in sensory perception of pain
GO:0051209; release of sequestered calcium ion into cytosol
GO:0051289; protein homotetramerization
GO:0060083; smooth muscle contraction involved in micturition
GO:0060454; positive regulation of gastric acid secretion
GO:0070588; calcium ion transmembrane transport
GO:0071312; cellular response to alkaloid
GO:0071318; cellular response to ATP
GO:0071356; cellular response to tumor necrosis factor
GO:0071468; cellular response to acidic pH
GO:0071502; cellular response to temperature stimulus
GO:0090212; negative regulation of establishment of blood-brain barrier
GO:1901594; response to capsazepine
GO:1990035; calcium ion import into cell
GO:1990090; cellular response to nerve growth factor stimulus

Cellular component:

GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral component of membrane
GO:0030054; cell junction
GO:0030425; dendrite
GO:0031226; intrinsic component of plasma membrane
GO:0032591; dendritic spine membrane
GO:0043025; neuronal cell body
GO:0045211; postsynaptic membrane

Function:

GO:0004888; transmembrane signaling receptor activity
GO:0005230; extracellular ligand-gated ion channel activity
GO:0005231; excitatory extracellular ligand-gated ion channel activity
GO:0005262; calcium channel activity
GO:0005516; calmodulin binding
GO:0005524; ATP binding
GO:0015278; calcium-release channel activity
GO:0017081; chloride channel regulator activity
GO:0035091; phosphatidylinositol binding
GO:0042802; identical protein binding
GO:0046872; metal ion binding
GO:0051219; phosphoprotein binding
GO:0097603; temperature-gated ion channel activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, TRPV1
STRING interaction network

Retrieve sequences for TRPV1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Trpv1
Rattus norvegicus: Trpv1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Trpv1