GenAge entry for TRPV1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 306)

HGNC symbol: TRPV1
Aliases: VR1
Common name: transient receptor potential cation channel subfamily V member 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Cytogenetic information

Cytogenetic band: 17p13.2
Location: 3,565,445 bp to 3,609,410 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001660; fever generation
GO:0001774; microglial cell activation
GO:0002024; diet induced thermogenesis
GO:0002790; peptide secretion
GO:0006629; lipid metabolic process
GO:0006810; transport
GO:0007166; cell surface receptor signaling pathway
GO:0007635; chemosensory behavior
GO:0014047; glutamate secretion
GO:0034605; cellular response to heat

And 24 more GO terms

Cellular component:	GO:0005829; cytosol GO:0005886; plasma membrane GO:0005887; integral component of plasma membrane GO:0009897; external side of plasma membrane GO:0016021; integral component of membrane GO:0030054; cell junction GO:0030425; dendrite GO:0031226; intrinsic component of plasma membrane GO:0032591; dendritic spine membrane GO:0043025; neuronal cell body GO:0045211; postsynaptic membrane
	And 1 more GO terms

Function:

GO:0004888; transmembrane signaling receptor activity
GO:0005230; extracellular ligand-gated ion channel activity
GO:0005231; excitatory extracellular ligand-gated ion channel activity
GO:0005262; calcium channel activity
GO:0005516; calmodulin binding
GO:0005524; ATP binding
GO:0015278; calcium-release channel activity
GO:0017081; chloride channel regulator activity
GO:0035091; phosphatidylinositol binding
GO:0042802; identical protein binding
GO:0046872; metal ion binding

And 3 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, TRPV1
STRING interaction network

Retrieve sequences for TRPV1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Trpv1
Rattus norvegicus: Trpv1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Trpv1