GenAge entry for UBB (Homo sapiens)
Gene name (HAGRID: 66)
- HGNC symbol
- UBB
- Aliases
- MGC8385; FLJ25987
- Common name
- ubiquitin B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
UBB is involved in the regulation of chromatin structure and stress response, as well as in the degradation of cellular proteins [439]. In lower life forms, such as invertebrates, stress-response proteins similar to UBB have been associated with ageing. UBB has also been associated with neurodegenerative diseases [436]. Although unproven, a role for UBB in ageing and/or age-related diseases is possible.
Cytogenetic information
- Cytogenetic band
- 17p12-p11.
- Location
- 16,380,797 bp to 16,382,745 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000209; protein polyubiquitination
GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0002755; MyD88-dependent toll-like receptor signaling pathway
GO:0002756; MyD88-independent toll-like receptor signaling pathway
GO:0005978; glycogen biosynthetic process
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007219; Notch signaling pathway
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007254; JNK cascade
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway
GO:0010939; regulation of necrotic cell death
GO:0016055; Wnt signaling pathway
GO:0016197; endosomal transport
GO:0016236; macroautophagy
GO:0019058; viral life cycle
GO:0019068; virion assembly
GO:0019985; translesion synthesis
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0031398; positive regulation of protein ubiquitination
GO:0032479; regulation of type I interferon production
GO:0032480; negative regulation of type I interferon production
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0033683; nucleotide-excision repair, DNA incision
GO:0034220; ion transmembrane transport
GO:0035666; TRIF-dependent toll-like receptor signaling pathway
GO:0036297; interstrand cross-link repair
GO:0038061; NIK/NF-kappaB signaling
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0038128; ERBB2 signaling pathway
GO:0042059; negative regulation of epidermal growth factor receptor signaling pathway
GO:0042276; error-prone translesion synthesis
GO:0042769; DNA damage response, detection of DNA damage
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488; regulation of mRNA stability
GO:0044267; cellular protein metabolic process
GO:0045087; innate immune response
GO:0045742; positive regulation of epidermal growth factor receptor signaling pathway
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0047497; mitochondrion transport along microtubule
GO:0048812; neuron projection morphogenesis
GO:0050852; T cell receptor signaling pathway
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051403; stress-activated MAPK cascade
GO:0051436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0051881; regulation of mitochondrial membrane potential
GO:0060071; Wnt signaling pathway, planar cell polarity pathway
GO:0061136; regulation of proteasomal protein catabolic process
GO:0061418; regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070423; nucleotide-binding oligomerization domain containing signaling pathway
GO:0070911; global genome nucleotide-excision repair
GO:0070987; error-free translesion synthesis
GO:0075733; intracellular transport of virus
GO:0090090; negative regulation of canonical Wnt signaling pathway
GO:0090263; positive regulation of canonical Wnt signaling pathway
GO:1901214; regulation of neuron death
GO:1901796; regulation of signal transduction by p53 class mediator
GO:1902255; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902527; positive regulation of protein monoubiquitination
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0010008; endosome membrane
GO:0030666; endocytic vesicle membrane
GO:0043005; neuron projection
GO:0043025; neuronal cell body
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0005515; protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, VCP, APP, CDKN1A, SPRTN
- STRING interaction network
