GenAge entry for AGTR1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 264)

HGNC symbol: AGTR1
Aliases: AT1; AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B
Common name: angiotensin II receptor, type 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: AGTR1 is a gene encoding for one of the Ang II type 1 receptors. Ang II is the central product of the renin-angiotensin system and plays a role in cardiac and renal pathologies. Disruption of AGTR1 in mice resulted in a significant prolongation of maximal lifespan compared to controls. The mice also developed less cardiac and vascular injury, and multiple organs from these mice displayed less oxidative damage [2148]. AGTR1 is involved in atherosclerosis [2151] and renal diseases [2152].

Cytogenetic information

Cytogenetic band: 3q24
Location: 148,697,871 bp to 148,743,003 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001558; regulation of cell growth
GO:0001822; kidney development
GO:0002018; renin-angiotensin regulation of aldosterone production
GO:0002034; regulation of blood vessel diameter by renin-angiotensin
GO:0003081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007266; Rho protein signal transduction
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0010873; positive regulation of cholesterol esterification

And 17 more GO terms

Cellular component:

GO:0005622; intracellular
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016021; integral component of membrane

Function:

GO:0001596; angiotensin type I receptor activity
GO:0004945; angiotensin type II receptor activity
GO:0005515; protein binding
GO:0031711; bradykinin receptor binding
GO:0046982; protein heterodimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: JAK2
STRING interaction network

Retrieve sequences for AGTR1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: agtr1b
Mus musculus: Agtr1a
Rattus norvegicus: Agtr1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Agtr1a

LongevityMap

This gene is present as AGTR1

Selected references

[2151] Campbell et al. (2010) "Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of Atherosclerosis." Am. J. Nephrol. 32(2):156-162 (PubMed)
[2150] Van Hee et al. (2010) "Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis." Environ. Health Perspect. 118(7):962-969 (PubMed)
[2149] Cassis et al. (2010) "Angiotensin receptors as determinants of life span." Pflugers Arch. 459(2):325-332 (PubMed)
[2148] Benigni et al. (2009) "Disruption of the Ang II type 1 receptor promotes longevity in mice." J. Clin. Invest. 119(3):524-530 (PubMed)
[2152] Gribouval et al. (2005) "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis." Nat. Genet. 37(9):964-968 (PubMed)