GenAge entry for BDNF (Homo sapiens)

Gene name (HAGRID: 191)

HGNC symbol: BDNF
Aliases
Common name: brain-derived neurotrophic factor

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems

Description

BDNF is a growth factor that promotes neuronal survival and is involved in numerous neuronal responses.

Mice with an accelerated postnatal rise in BDNF showed a precocious development of some CNS features [833]. BDNF-deficient mice showed normal levels of serotonergic neurons at an early age but premature age-associated decrements [834]. Polymorphisms in the human BDNF gene have been associated with memory and hippocampal function [1727]. Age-related changes in BDNF have also been reported in rats [59]. In rats, BDNF has also been associated with changes in the heart [1646]. Although it is plausible that BDNF plays a role in some age-related pathologies, such as neurodegenerative diseases, its impact on human ageing has not been elucidated.

Cytogenetic information

Cytogenetic band: 11p13
Location: 27,654,895 bp to 27,659,649 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007267; cell-cell signaling
GO:0007399; nervous system development
GO:0007411; axon guidance
GO:0007416; synapse assembly
GO:0010832; negative regulation of myotube differentiation
GO:0031547; brain-derived neurotrophic factor receptor signaling pathway
GO:0031550; positive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO:0043524; negative regulation of neuron apoptotic process
GO:0048668; collateral sprouting
GO:0048672; positive regulation of collateral sprouting
GO:0051965; positive regulation of synapse assembly

And 3 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005737; cytoplasm
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0005169; neurotrophin TRKB receptor binding
GO:0008083; growth factor activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: APP
STRING interaction network

Retrieve sequences for BDNF

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: bdnf
Mus musculus: Bdnf
Rattus norvegicus: Bdnf