GenAge entry for CTF1 (Homo sapiens)

Gene name (HAGRID: 304)

HGNC symbol: CTF1
Aliases: CT-1; CT1
Common name: cardiotrophin 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: Mice lacking cardiotrophin 1 (CTF1), an interleukin 6 family member which promotes fibrosis and arterial stiffness, display decreased arterial stiffness, developed less vascular fibrosis and live longer than wild type mice [3501].

Cytogenetic information

Cytogenetic band: 16p11.2
Location: 30,896,607 bp to 30,903,560 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007166; cell surface receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007399; nervous system development
GO:0007517; muscle organ development
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0048666; neuron development
GO:0048861; leukemia inhibitory factor signaling pathway

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space

Function:

GO:0005125; cytokine activity
GO:0005146; leukemia inhibitory factor receptor binding
GO:0005515; protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EP300, APP
STRING interaction network

Retrieve sequences for CTF1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Ctf1
Rattus norvegicus: Ctf1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ctf1