GenAge entry for GHRHR (Homo sapiens)

Gene name (HAGRID: 222)

HGNC symbol
GHRHR 
Aliases
 
Common name
growth hormone releasing hormone receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

GHRHR is mostly expressed in the pituitary and functions as the receptor for GHRH. Different splice variants appear to exist. Knock-out mice without GHRHR, called little mice, live about 25% longer than controls [5], but it is unclear whether their ageing process is delayed. Mutations in the human GHRHR gene have been associated with growth deficiency and dwarfism [1751], though there is no indication that these patients live longer. GHRHR might play a role in human ageing through the GH1/IGF1 axis.

Cytogenetic information

Cytogenetic band
7p14
Location
30,964,021 bp to 30,979,531 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007166; cell surface receptor signaling pathway
GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190; activation of adenylate cyclase activity
GO:0007595; lactation
GO:0008284; positive regulation of cell proliferation
GO:0008340; determination of adult lifespan
GO:0019933; cAMP-mediated signaling
GO:0030104; water homeostasis
GO:0030252; growth hormone secretion
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0033143; regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018; positive regulation of multicellular organism growth
GO:0042445; hormone metabolic process
GO:0043568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627; response to estrogen
GO:0046010; positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0048469; cell maturation
GO:0048609; multicellular organismal reproductive process
GO:0051246; regulation of protein metabolic process
GO:0051384; response to glucocorticoid
GO:0060124; positive regulation of growth hormone secretion
GO:0060133; somatotropin secreting cell development
GO:0071333; cellular response to glucose stimulus
Cellular component: GO:0005637; nuclear inner membrane
GO:0005640; nuclear outer membrane
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0016021; integral component of membrane
GO:0016363; nuclear matrix
GO:0030141; secretory granule
GO:0042383; sarcolemma
Function: GO:0004930; G-protein coupled receptor activity
GO:0005515; protein binding
GO:0016520; growth hormone-releasing hormone receptor activity
GO:0017046; peptide hormone binding
GO:0019838; growth factor binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHRH
STRING interaction network
Protein-Protein network diagram for GHRHR

Retrieve sequences for GHRHR

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Ghrhr
Rattus norvegicus
Ghrhr

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ghrhr
LongevityMap
  • This gene is present as GHRHR

Selected references

External links

EPD
ORF Accession
NM_000823
CDS Accession
NP_000814
OMIM
139191
HPRD
00748
Ensembl
GHRHR
UniProt/Swiss-Prot
GHRHR_HUMAN
GeneCards
GHRHR
Entrez Gene
2692
UniGene
767
GenAtlas
GHRHR
Internet
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