GenAge entry for GSR (Homo sapiens)
Gene name (HAGRID: 154)
- HGNC symbol
- GSR
- Aliases
- Common name
- glutathione reductase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
GSR is involved in redox regulation and oxidative defence. Overexpression of a GSR homologue in fruit flies extends lifespan in hyperoxia but not in normal conditions [208]. Local overexpression of GSR in the brain of mice results in increased anxiety-like behaviour while inhibition decreased the anxiety-like behaviour [1712]. There is no evidence directly linking GSR to human ageing.
Cytogenetic information
- Cytogenetic band
- 8p21.1
- Location
- 30,678,063 bp to 30,727,969 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0006749; glutathione metabolic process
GO:0015949; nucleobase-containing small molecule interconversion
GO:0045454; cell redox homeostasis
GO:0055114; oxidation-reduction process
GO:0098869; cellular oxidant detoxification
Cellular component: GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0009897; external side of plasma membrane
GO:0070062; extracellular exosome
Show all GO termsFunction: GO:0004362; glutathione-disulfide reductase activity
GO:0009055; electron carrier activity
GO:0050660; flavin adenine dinucleotide binding
GO:0050661; NADP binding
Protein interactions and network
Retrieve sequences for GSR
Homologs in model organisms
- Caenorhabditis elegans
- gsr-1
- Danio rerio
- gsr
- Mus musculus
- Gsr
- Rattus norvegicus
- Gsr
- Saccharomyces cerevisiae
- GLR1
- Schizosaccharomyces pombe
- pgr1
In other databases
- LongevityMap
- This gene is present as GSR