GenAge entry for GSS (Homo sapiens)

Gene name (HAGRID: 155)

HGNC symbol: GSS
Aliases
Common name: glutathione synthetase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: GSS is involved in redox regulation and oxidative defence. Mutations in the human GSS gene cause 5-oxoprolinuria [744]. There is no evidence directly linking GSS to ageing in humans or in model organisms.

Cytogenetic information

Cytogenetic band: 20q11.2
Location: 34,928,433 bp to 34,955,798 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006520; cellular amino acid metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007399; nervous system development
GO:0007568; aging
GO:0009410; response to xenobiotic stimulus
GO:0031667; response to nutrient levels
GO:0034612; response to tumor necrosis factor
GO:0043200; response to amino acid
GO:0046686; response to cadmium ion

Cellular component:

GO:0005829; cytosol
GO:0070062; extracellular exosome

Function:

GO:0000287; magnesium ion binding
GO:0004363; glutathione synthase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016594; glycine binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043295; glutathione binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TERF1, GSS
STRING interaction network

Retrieve sequences for GSS

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gss-1
Danio rerio: gss
Drosophila melanogaster: GS
Mus musculus: Gss
Rattus norvegicus: Gss
Saccharomyces cerevisiae: GSH2
Schizosaccharomyces pombe: gsa1

In other databases

LongevityMap

This gene is present as GSS