GenAge entry for JUND (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 45)

HGNC symbol: JUND
Aliases: AP-1
Common name: jun D proto-oncogene

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

A possible oncogene and transcriptional activator, JUND is part of the AP-1 redox-regulated transcription complex that may play a role in some age-related changes [264]. The exact relation of AP-1 to human ageing is unclear, however.

Mice lacking junD exhibited persistent hypoglycemia due to enhanced insulin secretion and features of premature aging (cataracts, slight hair loss, graying, varying degrees of cachexia, and lordokyphosis), and had a shortened lifespan [2136]. An impaired activation of AP-1 and altered expression of constituent proteins in adrenal nuclear extracts from rats was also observed during ageing [358]. A similar change was seen during the ageing of human fibroblasts [2137].

Cytogenetic information

Cytogenetic band: 19p13.2
Location: 18,279,694 bp to 18,281,656 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002076; osteoblast development
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0007568; aging
GO:0007623; circadian rhythm
GO:0009314; response to radiation
GO:0009416; response to light stimulus
GO:0009612; response to mechanical stimulus
GO:0010941; regulation of cell death
GO:0032496; response to lipopolysaccharide

And 12 more GO terms

Cellular component:

GO:0000785; chromatin
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005667; transcription factor complex
GO:0032993; protein-DNA complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0019899; enzyme binding
GO:0044212; transcription regulatory region DNA binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: FOS, BRCA1, EGR1, EP300, SIRT1, MAPK8, JUN, MAPK9, CREB1, DDIT3, MDM2, PPARG
STRING interaction network

Retrieve sequences for JUND

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: jund
Mus musculus: Jund
Rattus norvegicus: Jund

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Jund