GenAge entry for MAPK9 (Homo sapiens)

Gene name (HAGRID: 174)

HGNC symbol: MAPK9
Aliases: JNK2; p54a; SAPK; PRKM9
Common name: mitogen-activated protein kinase 9

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: Also called JNK2, MAPK9 encodes many transcripts and is an important player in stress response. In invertebrates, there is evidence linking JNK signalling to ageing. Fruit flies with mutations that augment JNK signalling live longer [212]. Overexpression of JNK in roundworms also increases lifespan [60]. Mice without MAPK8 and MAPK9 die at embryonic stages. MAPK9-null mice develop normally [786], but are defective in peripheral T-cell activation [1721]. Further research is needed to determine whether MAPK9 is related to human ageing.

Cytogenetic information

Cytogenetic band: 5q35
Location: 180,233,595 bp to 180,292,071 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007254; JNK cascade
GO:0007258; JUN phosphorylation
GO:0010628; positive regulation of gene expression
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042752; regulation of circadian rhythm
GO:0046686; response to cadmium ion
GO:0048511; rhythmic process
GO:0051090; regulation of sequence-specific DNA binding transcription factor activity

And 3 more GO terms

Cellular component:

GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol

Function:

GO:0004705; JUN kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, AKT1, EGFR, JUND, FOS, PRKDC, GRB2, HDAC1, MAPK8, JUN, MAPK9, ATF2, CLU, CTNNB1, CSNK1E, CDC42, NFE2L2
STRING interaction network

Retrieve sequences for MAPK9

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: jnk-1
Danio rerio: mapk9
Drosophila melanogaster: bsk
Mus musculus: Mapk9
Rattus norvegicus: Mapk9

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as jnk-1
A homolog of this gene for Drosophila melanogaster is present as bsk

CellAge

This gene is present as MAPK9