GenAge entry for MXI1 (Homo sapiens)
Gene name (HAGRID: 90)
- HGNC symbol
- MXI1
- Aliases
- MXD2; MAD2; MXI; bHLHc11
- Common name
- MAX interactor 1, dimerization protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
MXI1 is an antagonist of MYC in that it competes with MYC for MAX [945]. Mice lacking MXI1 exhibit progressive, multisystem abnormalities and increased susceptibility to tumorigenesis. A role for MXI1 in murine ageing has thus been suggested [887]. Mutations in the human MXI1 gene have been linked to cancer [944]. Additional, more detailed, studies are necessary to determine whether MXI1 is related to human ageing.
Cytogenetic information
- Cytogenetic band
- 10q24-q25
- Location
- 110,226,004 bp to 110,287,365 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0008285; negative regulation of cell proliferation
GO:0042994; cytoplasmic sequestering of transcription factor
GO:1903507; negative regulation of nucleic acid-templated transcription
Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
Show all GO termsFunction: GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity
Protein interactions and network
Retrieve sequences for MXI1
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as MXI1