GenAge entry for RAE1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 241)

HGNC symbol: RAE1
Aliases: Mnrp41
Common name: ribonucleic acid export 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: In yeast, RAE1 is involved in RNA export. Probably, RAE1 is involved in nucleocytoplasmic transport. The RAE1 gene encodes different isoforms. Haploinsufficiency of both RAE1 and BUB3 in mice, but not haploinsufficiency of either gene by itself, reduces lifespan and appears to accelerate ageing [1594]. RAE1-null mice are embryonic lethal [1597].

Cytogenetic information

Cytogenetic band: 20q13.31
Location: 57,351,089 bp to 57,378,463 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000972; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006406; mRNA export from nucleus
GO:0006409; tRNA export from nucleus
GO:0006606; protein import into nucleus
GO:0007077; mitotic nuclear envelope disassembly
GO:0010827; regulation of glucose transport
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0019083; viral transcription
GO:0031047; gene silencing by RNA
GO:0071407; cellular response to organic cyclic compound

And 3 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005643; nuclear pore
GO:0005730; nucleolus
GO:0005737; cytoplasm

Function:

GO:0003723; RNA binding
GO:0008017; microtubule binding
GO:0043130; ubiquitin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TXN, SOD1, BUB1B, POLA1, GSK3A
STRING interaction network

Retrieve sequences for RAE1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: npp-17
Danio rerio: rae1
Drosophila melanogaster: Rae1
Mus musculus: Rae1
Rattus norvegicus: Rae1
Saccharomyces cerevisiae: GLE2
Schizosaccharomyces pombe: rae1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Rae1