GenAge entry for GSK3A (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 295)

HGNC symbol: GSK3A
Aliases
Common name: glycogen synthase kinase 3 alpha

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: GSK3A is involved in the control of several other proteins, including JUN, and signaling pathways like WNT and PI3K. It has been associated with Alzheimer disease [3426]. In mice, knockout of GSK3A results in a phenotype resembling accelerated ageing, including premature death, cardiac abnormalities and sarcopenia [3256].

Cytogenetic information

Cytogenetic band: 19q13.2
Location: 42,230,186 bp to 42,242,584 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0003073; regulation of systemic arterial blood pressure
GO:0003214; cardiac left ventricle morphogenesis
GO:0005977; glycogen metabolic process
GO:0006468; protein phosphorylation
GO:0007212; dopamine receptor signaling pathway
GO:0007399; nervous system development
GO:0008286; insulin receptor signaling pathway
GO:0010905; negative regulation of UDP-glucose catabolic process
GO:0016055; Wnt signaling pathway
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032007; negative regulation of TOR signaling

And 22 more GO terms

Cellular component:

GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0030877; beta-catenin destruction complex
GO:0098794; postsynapse

Function:

GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0034236; protein kinase A catalytic subunit binding
GO:0050321; tau-protein kinase activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, MYC, PRKCD, HSP90AA1, PRKCA, PRKDC, AR, FOXM1, CREB1, MAPT, CTNNB1, RAE1, RICTOR
STRING interaction network

Retrieve sequences for GSK3A

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gsk-3
Danio rerio: gsk3aa
Mus musculus: Gsk3a
Rattus norvegicus: Gsk3a
Schizosaccharomyces pombe: gsk3

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Gsk3a
A homolog of this gene for Schizosaccharomyces pombe is present as gsk3

CellAge

This gene is present as GSK3A