GenAge entry for SDHC (Homo sapiens)
Gene name (HAGRID: 182)
- HGNC symbol
- SDHC
- Aliases
- CYB560; PGL3
- Common name
- succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
A member of the mitochondrial electron transport chain, SDHC homologues have been implicated in ageing of lower life forms. In roundworms, mutations in a SDHC homologue have been reported to cause oxidative stress and premature ageing [799]. Mutations in the human SDHC gene have been associated with mitochondrial respiratory chain deficiency [798], but not with premature ageing. Whether SDHC influences human ageing has not been determined.
Cytogenetic information
- Cytogenetic band
- 1q23.3
- Location
- 161,314,376 bp to 161,364,745 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006099; tricarboxylic acid cycle
GO:0006121; mitochondrial electron transport, succinate to ubiquinone
GO:0009060; aerobic respiration
GO:0055114; oxidation-reduction process
Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005749; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
GO:0016021; integral component of membrane
GO:0045273; respiratory chain complex II
Show all GO termsFunction: GO:0000104; succinate dehydrogenase activity
GO:0009055; electron carrier activity
GO:0020037; heme binding
GO:0046872; metal ion binding
Protein interactions and network
Retrieve sequences for SDHC
Homologs in model organisms
- Caenorhabditis elegans
- mev-1
- Danio rerio
- sdhc
- Drosophila melanogaster
- SdhC
- Mus musculus
- Sdhc
- Rattus norvegicus
- Sdhc
- Saccharomyces cerevisiae
- SDH3
- Schizosaccharomyces pombe
- sdh3
In other databases
- GenAge model organism genes