GenAge entry for TBP (Homo sapiens)
Gene name (HAGRID: 194)
- HGNC symbol
- TBP
- Aliases
- TFIID; GTF2D1; SCA17
- Common name
- TATA box binding protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
TBP is part of the TFIID general transcription factor. Because of its central role in the activation of eukaryotic genes, TBP is potentially involved in a large variety of processes. TBP-null mice die at embryonic stages [848]. Mutations in the human TBP gene have been associated with neurological diseases [846]. Although TBP has not been directly linked to human ageing, because it is involved in so many different processes, and potentially in neurodegenerative diseases, it is possible that TBP plays some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 6q27
- Location
- 170,554,333 bp to 170,572,870 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006359; regulation of transcription from RNA polymerase III promoter
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
GO:0006363; termination of RNA polymerase I transcription
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006383; transcription from RNA polymerase III promoter
GO:0007283; spermatogenesis
GO:0016032; viral process
GO:0042795; snRNA transcription from RNA polymerase II promoter
And 4 more GO terms Cellular component: GO:0000790; nuclear chromatin
GO:0001939; female pronucleus
GO:0001940; male pronucleus
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005669; transcription factor TFIID complex
GO:0005672; transcription factor TFIIA complex
GO:0005719; nuclear euchromatin
GO:0005737; cytoplasm
Show all GO termsFunction: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001034; RNA polymerase III transcription factor activity, sequence-specific DNA binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0044212; transcription regulatory region DNA binding
GO:0070491; repressing transcription factor binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, E2F1, MYC, FOS, CREBBP, NR3C1, UBE2I, EP300, AR, RB1, HSF1, RELA, ERCC1, HDAC1, SP1, JUN, HMGB1, TAF1, TBP, SIN3A, MAX, MDM2, ESR1
- STRING interaction network
