GenAge entry for TGFB1 (Homo sapiens)

Gene name (HAGRID: 91)

HGNC symbol: TGFB1
Aliases: CED; TGFbeta; TGFB; DPD1
Common name: transforming growth factor, beta 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: TGFB1 is an important growth factor in development and differentiation. Some evidence suggests TGFB1 is involved in the response to oxidative stress [137]. In roundworms, it has been argued that a TGFB signalling pathway acts downstream of other signals to repress body size and lifespan [1703]. Mutations in TGFB1 have been linked to several pathologies in humans [500], and a polymorphism in this gene has been associated with human longevity [1254]. Nonetheless, it is unclear if/how TGFB1 influences human ageing.

Cytogenetic information

Cytogenetic band: 19q13.1
Location: 41,330,531 bp to 41,353,933 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000060; protein import into nucleus, translocation
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001570; vasculogenesis
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0001837; epithelial to mesenchymal transition
GO:0001843; neural tube closure
GO:0001933; negative regulation of protein phosphorylation
GO:0001934; positive regulation of protein phosphorylation
GO:0002028; regulation of sodium ion transport

And 170 more GO terms

Cellular component:	GO:0005576; extracellular region GO:0005578; proteinaceous extracellular matrix GO:0005615; extracellular space GO:0005634; nucleus GO:0005737; cytoplasm GO:0005796; Golgi lumen GO:0005886; plasma membrane GO:0005902; microvillus GO:0009986; cell surface GO:0030424; axon GO:0031012; extracellular matrix
	And 4 more GO terms

Function:

GO:0001948; glycoprotein binding
GO:0003823; antigen binding
GO:0005114; type II transforming growth factor beta receptor binding
GO:0005125; cytokine activity
GO:0005160; transforming growth factor beta receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0019899; enzyme binding
GO:0034713; type I transforming growth factor beta receptor binding
GO:0034714; type III transforming growth factor beta receptor binding
GO:0042803; protein homodimerization activity

And 4 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: APP
STRING interaction network

Retrieve sequences for TGFB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Tgfb1
Rattus norvegicus: Tgfb1

In other databases

LongevityMap

This gene is present as TGFB1