LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: American (Caucasian), French
Study Design: A haplotype-based fine-mapping study was performed in 653 individuals (456 females, >= 98 years, mean age = 100.8 years) and controls (< 50 years, mean age = 38.6 years). Then, the identified haplotype marker was tested in 564 French (472 females, >= 99 years, mean age = 103.1 years) and 564 controls (18- 70 years, mean age = 51.2 years).
Conclusions: Although the association was not replicated in French cohort, there was evidence for statistical distortion in the form of Hardy–Weinberg disequilibrium.

HGNC symbol: MTTP
Aliases: ABL; MTP
Common name: microsomal triglyceride transfer protein
Description: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 20
OMIM: 157147
Ensembl: ENSG00000138823
UniProt/Swiss-Prot: B7Z7X3_HUMAN
Entrez Gene: 4547
UniGene: 195799
HapMap: View on HapMap