GenAge entry for EGR1 (Homo sapiens)

Gene name (HAGRID: 76)

HGNC symbol: EGR1
Aliases: TIS8; G0S30; NGFI-A; KROX-24; ZIF-268; AT225; ZNF225
Common name: early growth response 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 [163]. It also appears to be pro-apoptotic [466]. EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing.

Cytogenetic information

Cytogenetic band: 5q31.1
Location: 138,465,492 bp to 138,469,315 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0002931; response to ischemia
GO:0006366; transcription from RNA polymerase II promoter
GO:0009749; response to glucose
GO:0030217; T cell differentiation
GO:0030509; BMP signaling pathway
GO:0032868; response to insulin
GO:0033233; regulation of protein sumoylation
GO:0035914; skeletal muscle cell differentiation
GO:0042981; regulation of apoptotic process

And 18 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm

Function:

GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0010385; double-stranded methylated DNA binding
GO:0035035; histone acetyltransferase binding
GO:0043565; sequence-specific DNA binding
GO:0044729; hemi-methylated DNA-binding

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, JUND, PTEN, CREBBP, CEBPB, EP300, RELA, SP1, MDM2, CTNNB1, CDKN2A
STRING interaction network

Retrieve sequences for EGR1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: egrh-2
Danio rerio: egr1
Mus musculus: Egr1
Rattus norvegicus: Egr1
Schizosaccharomyces pombe: prz1

In other databases

CellAge gene expression

This gene is present as EGR1