GenAge entry for FAS (Homo sapiens)

Gene name (HAGRID: 115)

HGNC symbol: FAS
Aliases: CD95; APO-1; FAS1; APT1; TNFRSF6
Common name: Fas cell surface death receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: FAS encodes multiple transcripts involved in apoptosis and development. It is also related to cancer progression. The expression level of FAS changes during ageing [937], and there are some results correlating FAS with age-related changes [1170]. Nonetheless, polymorphisms in human FAS have not been associated with human longevity [935].

Cytogenetic information

Cytogenetic band: 10q24.1
Location: 88,990,531 bp to 89,015,785 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002377; immunoglobulin production
GO:0003014; renal system process
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924; activation-induced cell death of T cells
GO:0006925; inflammatory cell apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007420; brain development

And 36 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005737; cytoplasm GO:0005829; cytosol GO:0005886; plasma membrane GO:0005887; integral component of plasma membrane GO:0009897; external side of plasma membrane GO:0009986; cell surface GO:0031264; death-inducing signaling complex GO:0031265; CD95 death-inducing signaling complex GO:0043005; neuron projection GO:0045121; membrane raft
	And 2 more GO terms

Function:

GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0019900; kinase binding
GO:0042802; identical protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: UBE2I, TNF, PML, PRKCA, FAS, RB1, MAPK8, MAP3K5, EEF1A1, SUMO1, CTNNB1, TP63, SQSTM1
STRING interaction network

Retrieve sequences for FAS

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: fas
Mus musculus: Fas
Rattus norvegicus: Fas

In other databases

LongevityMap

This gene is present as FAS

CellAge gene expression

This gene is present as FAS