GenAge entry for HIF1A (Homo sapiens)

Gene name (HAGRID: 65)

HGNC symbol: HIF1A
Aliases: MOP1; HIF-1alpha; PASD8; HIF1; bHLHe78
Common name: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: HIF1A is a transcription factor that responds to oxidative stress and oxygen [435]. Changes in HIF1A with age have been reported in rats and could be related to age-related pathologies [1593], such as neurodegeneration [1534]. Deficiencies in HIF1A have not been associated with ageing in mice [434]. Further evidence is needed to directly link HIF1A to human ageing.

Cytogenetic information

Cytogenetic band: 14q23.2
Location: 61,695,401 bp to 61,748,259 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0001666; response to hypoxia
GO:0001755; neural crest cell migration
GO:0001837; epithelial to mesenchymal transition
GO:0001892; embryonic placenta development
GO:0001922; B-1 B cell homeostasis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0001947; heart looping
GO:0002052; positive regulation of neuroblast proliferation
GO:0002248; connective tissue replacement involved in inflammatory response wound healing
GO:0003151; outflow tract morphogenesis

And 63 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0031514; motile cilium
GO:0090575; RNA polymerase II transcription factor complex
GO:1904115; axon cytoplasm

Function:

GO:0000989; transcription factor activity, transcription factor binding
GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding

And 8 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, ATM, STAT3, HDAC3, MYC, PARP1, BRCA1, CREBBP, BCL2, VCP, HSP90AA1, UBE2I, EP300, RB1, RELA, HDAC1, SP1, JUN, APEX1, HSPA8, SIN3A, HDAC2, MAX, MDM2, ESR1, CTNNB1, CDKN2A, STUB1, ARNTL, SQSTM1
STRING interaction network

Retrieve sequences for HIF1A

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: hif1ab
Mus musculus: Hif1a
Rattus norvegicus: Hif1a

In other databases

LongevityMap

This gene is present as HIF1A

CellAge

This gene is present as HIF1A