GenAge entry for PARP1 (Homo sapiens)

Gene name (HAGRID: 60)

HGNC symbol: PARP1
Aliases: PARP; PPOL; ADPRT
Common name: poly (ADP-ribose) polymerase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: The PARP1 enzyme catalyses the transfer of ADP-ribose to a variety of nuclear proteins including members of the high mobility group box and topoisomerase families [984]. It is involved in a variety of processes such as proliferation, differentiation, and recovery from DNA damage [407]. PARP1's levels appear to inversely correlate with mammalian lifespan and PARP1 has been hinted as a determinant of mammalian ageing [68]. PARP1 is a critical mediator of axon growth inhibition. Pharmacological inhibition or genetic loss of PARP1in mouse cells markedly facilitates axon regeneration, thus making PARP1 a potential target to reverse neurological disability [4346]. Nonetheless, more detailed studies are necessary to investigate a role for PARP1 in ageing.

Cytogenetic information

Cytogenetic band: 1q41-q42
Location: 226,360,691 bp to 226,408,100 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0000724; double-strand break repair via homologous recombination
GO:0006273; lagging strand elongation
GO:0006281; DNA repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302; double-strand break repair

And 39 more GO terms

Cellular component:

GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005739; mitochondrion
GO:0016020; membrane
GO:0043234; protein complex

Function:	GO:0003677; DNA binding GO:0003910; DNA ligase (ATP) activity GO:0003950; NAD+ ADP-ribosyltransferase activity GO:0005515; protein binding GO:0008134; transcription factor binding GO:0008270; zinc ion binding GO:0019899; enzyme binding GO:0019901; protein kinase binding GO:0030331; estrogen receptor binding GO:0042802; identical protein binding GO:0042826; histone deacetylase binding
	And 5 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, WRN, LMNA, HDAC3, PARP1, BRCA1, CREBBP, HIF1A, RPA1, BLM, BCL2, ABL1, TOP2B, NFKB1, TOP1, UBE2I, ERCC6, EP300, PRKDC, XRCC5, PCNA, XRCC6, FOXO1, SIRT1, HDAC1, PTK2, SP1, JUN, MED1, BMI1, E2F1, HDAC2, POLA1, RELA, TCF3, H2AFX, HOXB7, BUB1B, APTX, CEBPA, ESR1, CTNNB1, POLB, BUB3, CDKN1A
STRING interaction network

Retrieve sequences for PARP1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: pme-1
Danio rerio: parp1
Drosophila melanogaster: Parp
Mus musculus: Parp1
Rattus norvegicus: Parp1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as pme-1

LongevityMap

This gene is present as PARP1

CellAge

This gene is present as PARP1

CellAge gene expression

This gene is present as PARP1