GenAge entry for HDAC2 (Homo sapiens)

Gene name (HAGRID: 207)

HGNC symbol: HDAC2
Aliases: RPD3; YAF1
Common name: histone deacetylase 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: HDAC2 performs the deacetylation of histones and is an important player in may processes such as development, transcriptional regulation, and cell cycle progression [736]. Homologues of HDAC2 have been linked to longevity in yeast [203] and to ageing and caloric restriction in fruit flies [202]. Whether HDAC2 is involved in human ageing, however, is not known.

Cytogenetic information

Cytogenetic band: 6q21
Location: 113,936,156 bp to 113,971,195 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001975; response to amphetamine
GO:0003300; cardiac muscle hypertrophy
GO:0006338; chromatin remodeling
GO:0006344; maintenance of chromatin silencing
GO:0006351; transcription, DNA-templated
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0009913; epidermal cell differentiation
GO:0010718; positive regulation of epithelial to mesenchymal transition
GO:0010870; positive regulation of receptor biosynthetic process

And 41 more GO terms

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016580; Sin3 complex
GO:0016581; NuRD complex
GO:0035098; ESC/E(Z) complex
GO:0043234; protein complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0003682; chromatin binding
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019213; deacetylase activity
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding

And 7 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, STAT3, IRS1, MYC, PARP1, BRCA1, CREBBP, HIF1A, TOP2A, TOP2B, NFKB1, PML, RB1, HSF1, SIRT1, HDAC1, SP1, CCNA2, CREB1, APEX1, SIN3A, HDAC2, MXD1, RELA, TCF3, NR3C1, HELLS, CEBPA, ESR1, NFKBIA, SIRT6, BUB3, ATR, SIRT7, NCOR2, TP73, NFE2L2, CDKN1A, CDK7
STRING interaction network

Retrieve sequences for HDAC2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: hda-1
Mus musculus: Hdac2
Rattus norvegicus: Hdac2
Schizosaccharomyces pombe: clr6

In other databases

CellAge

This gene is present as HDAC2