GenAge entry for HTT (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 98)

HGNC symbol: HTT
Aliases: IT15; HD
Common name: huntingtin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: Mostly famous for causing Huntington disease, the exact functions of HTT are still unknown. While HTT appears to be involved in age-related changes [836], its exact role in human ageing is still being studied. In mice however, the deletion of the polyglutamine stretch resulted in the extension of mean and maximal lifespan [2135].

Cytogenetic information

Cytogenetic band: 4p16.3
Location: 3,074,510 bp to 3,243,960 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000132; establishment of mitotic spindle orientation
GO:0006890; retrograde vesicle-mediated transport, Golgi to ER
GO:0006915; apoptotic process
GO:0007030; Golgi organization
GO:0031587; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0034047; regulation of protein phosphatase type 2A activity
GO:0042297; vocal learning
GO:0045724; positive regulation of cilium assembly
GO:0047496; vesicle transport along microtubule
GO:0048513; animal organ development
GO:1903599; positive regulation of mitophagy

And 4 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005770; late endosome GO:0005776; autophagosome GO:0005783; endoplasmic reticulum GO:0005794; Golgi apparatus GO:0005814; centriole GO:0005829; cytosol GO:0030424; axon GO:0030425; dendrite
	And 3 more GO terms

Function:

GO:0002039; p53 binding
GO:0005515; protein binding
GO:0005522; profilin binding
GO:0008134; transcription factor binding
GO:0019900; kinase binding
GO:0034452; dynactin binding
GO:0042802; identical protein binding
GO:0044325; ion channel binding
GO:0045505; dynein intermediate chain binding
GO:0048487; beta-tubulin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, EGFR, NCOR1, CREBBP, VCP, PML, HTT, XRCC6, GRB2, SP1, MAPK3, PIK3R1, CREB1, HSPA8, HOXC4, CTNNB1, IKBKB, SQSTM1
STRING interaction network

Retrieve sequences for HTT

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: htt
Drosophila melanogaster: htt
Mus musculus: Htt
Rattus norvegicus: Htt

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Htt