GenAge entry for PTEN (Homo sapiens)

Gene name (HAGRID: 63)

HGNC symbol: PTEN
Aliases: MMAC1; TEP1; PTEN1; BZS; MHAM
Common name: phosphatase and tensin homolog

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: PTEN is a tumour suppressor involved in cell cycle progression as an inhibitor of insulin (INS) signalling. In roundworms, a PTEN homologue has been related to development and longevity regulation through the INS-like pathway [1348]. The same gene has been shown to mediate nutrient-dependent cell cycle arrest and growth in the germline of roundworms [1771]. PTEN-null mice die at embryonic stages while heterozygous animals develop tumours [1757]. In mice lacking PTEN in oocytes the entire primordial follicle pool becomes activated and thus all primordial follicles become depleted in early adulthood causing premature ovarian failure [1905]. Mice carrying additional copies of PTEN are protected from cancer and present a modest (16%) extension of life span that is independent of their lower cancer incidence [2457]. Mutations in the human PTEN gene have been associated with cancer [1577], and further studies are necessary to determine whether PTEN plays a role in human ageing.

Cytogenetic information

Cytogenetic band: 10q23.3
Location: 87,863,438 bp to 87,971,930 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001525; angiogenesis
GO:0001933; negative regulation of protein phosphorylation
GO:0002902; regulation of B cell apoptotic process
GO:0006470; protein dephosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0006915; apoptotic process
GO:0007270; neuron-neuron synaptic transmission
GO:0007416; synapse assembly
GO:0007417; central nervous system development
GO:0007507; heart development

And 82 more GO terms

Cellular component:	GO:0005576; extracellular region GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005829; cytosol GO:0005886; plasma membrane GO:0009898; cytoplasmic side of plasma membrane GO:0016324; apical plasma membrane GO:0016605; PML body GO:0035749; myelin sheath adaxonal region
	And 6 more GO terms

Function:

GO:0000287; magnesium ion binding
GO:0004438; phosphatidylinositol-3-phosphatase activity
GO:0004721; phosphoprotein phosphatase activity
GO:0004722; protein serine/threonine phosphatase activity
GO:0004725; protein tyrosine phosphatase activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0008138; protein tyrosine/serine/threonine phosphatase activity
GO:0008289; lipid binding
GO:0010997; anaphase-promoting complex binding
GO:0016314; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

And 7 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TXN, AKT1, PDGFRB, HSP90AA1, EGR1, UBE2I, EEF2, AR, PRDX1, HSPD1, HSPA1A, PTK2B, PTK2, BMI1, HSPA8, MXD1, ESR1, CTNNB1, PPP1CA, DBN1, STUB1, PDGFRA
STRING interaction network

Retrieve sequences for PTEN

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ptena
Drosophila melanogaster: Pten
Mus musculus: Pten
Rattus norvegicus: Pten

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Pten
A homolog of this gene for Mus musculus is present as Pten

CellAge

This gene is present as PTEN