GenAge entry for AKT1 (Homo sapiens)

Gene name (HAGRID: 35)

HGNC symbol: AKT1
Aliases: RAC; PKB; PRKBA; AKT
Common name: v-akt murine thymoma viral oncogene homolog 1

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

AKT1 is a protein kinase that is also considered an oncogene. It appears to mediate insulin's (INS) actions and be involved in the signal transduction of growth factors such as IGF1. AKT1 also impacts on cell survival and development, and it activates NFKB1 [333]. AKT1 null mice are smaller but viable and more susceptible to genotoxic stress and apoptosis [327]. Haploinsufficient mice have a lower body weight and a slightly longer lifespan (8% for males and 15% for females) [3259].

In roundworms, two AKT1 homologues play a role in insulin-like signalling and influence dauer formation [948]. Knockdown of akt-1 in roundworms extended lifespan [3259]. AKT1 also appears to play a role in cellular senescence [1660]. Some evidence suggests AKT1 may play a role in ageing through its impact on energy metabolism [823], but its role, if any, on human ageing remains elusive.

Cytogenetic information

Cytogenetic band: 14q32.32
Location: 104,769,350 bp to 104,793,601 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000060; protein import into nucleus, translocation
GO:0001649; osteoblast differentiation
GO:0001893; maternal placenta development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0005978; glycogen biosynthetic process
GO:0005979; regulation of glycogen biosynthetic process
GO:0006006; glucose metabolic process
GO:0006412; translation
GO:0006417; regulation of translation
GO:0006464; cellular protein modification process

And 109 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005819; spindle GO:0005829; cytosol GO:0005886; plasma membrane GO:0005911; cell-cell junction GO:0015630; microtubule cytoskeleton GO:0031982; vesicle GO:0036064; ciliary basal body
	And 3 more GO terms

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004712; protein serine/threonine/tyrosine kinase activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0005547; phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016301; kinase activity
GO:0019899; enzyme binding
GO:0030235; nitric-oxide synthase regulator activity
GO:0032794; GTPase activating protein binding

And 5 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TERT, HDAC3, IRS1, AKT1, PIK3CB, EGFR, BRCA1, PTEN, CREBBP, VCP, HSP90AA1, PDPK1, EP300, GSK3B, PRKDC, AR, FOXO3, FOXO1, UCHL1, APP, SIRT1, HSPA9, MAPK8, YWHAZ, MAPK14, MAPK9, MAP3K5, FOXO4, CREB1, HSPA8, MAPT, MXD1, MDM2, ESR1, MTOR, CTNNB1, PPP1CA, SIRT6, STUB1, NCOR2, NFE2L2, CDKN1A, PIK3CA, GSK3A, IKBKB, RICTOR
STRING interaction network

Retrieve sequences for AKT1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Akt1
Rattus norvegicus: Akt1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Akt1

LongevityMap

This gene is present as AKT1

CellAge

This gene is present as AKT1