GenAge entry for DBN1 (Homo sapiens)
Gene name (HAGRID: 228)
- HGNC symbol
- DBN1
- Aliases
- D0S117E
- Common name
- drebrin 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
DBN1 is thought to be involved in neuronal growth. In a mouse model of Alzheimer's disease, DBN1 levels were found to decline with age [1666]. DBN1 could thus play a role and neurodegenerative diseases.
Cytogenetic information
- Cytogenetic band
- 5q35.3
- Location
- 177,456,613 bp to 177,473,693 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007015; actin filament organization
GO:0010643; cell communication by chemical coupling
GO:0010644; cell communication by electrical coupling
GO:0032507; maintenance of protein location in cell
GO:0048168; regulation of neuronal synaptic plasticity
GO:0050773; regulation of dendrite development
GO:0061351; neural precursor cell proliferation
GO:0098609; cell-cell adhesion
Cellular component: GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0005921; gap junction
GO:0005938; cell cortex
GO:0015629; actin cytoskeleton
GO:0030425; dendrite
GO:0030426; growth cone
GO:0042641; actomyosin
Show all GO termsFunction: GO:0003779; actin binding
GO:0005515; protein binding
GO:0005522; profilin binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, PTEN, TERF1, GRB2, SP1, BMI1, ESR1, PPP1CA, CDC42, BAK1
- STRING interaction network
