GenAge entry for SOD1 (Homo sapiens)

Gene name (HAGRID: 130)

HGNC symbol: SOD1
Aliases: IPOA; ALS; ALS1
Common name: superoxide dismutase 1, soluble

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

SOD1 is an antioxidant. It is the predominant member of the SOD family found in the cytoplasm. Initial results from invertebrates suggested a role for SOD1 in ageing. Overexpression of SOD1 and CAT in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40].

Early SOD1-null mice models were found to develop normally and did not show signs of premature ageing, though they were vulnerable to motor neuron loss after axonal injury [45]. In a more recent study the kidneys of SOD1-null mice exhibited increased DNA damage, increased senescent cells, and increased inflammation. Subjecting these mice to dietary restriction attenuated these effects [4485]. SMP30RGN/SOD1-double knockout mice exhibit abnormal plasma lipid metabolism, hepatic lipid accumulation and premature death resulting from impaired VLDL secretion, both compared to wild type, SMP30-knockout and SOD1-knockout mice [3618]. Overexpression of human SOD1 in transgenic mice results in neurodegenerative changes [663]. In humans, mutations in SOD1 have been associated with amyotrophic lateral sclerosis [671]. A role for SOD1 in human ageing, while not impossible, remains to be determined.

Cytogenetic information

Cytogenetic band: 21q22.11
Location: 31,659,622 bp to 31,668,930 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000187; activation of MAPK activity
GO:0000302; response to reactive oxygen species
GO:0000303; response to superoxide
GO:0001541; ovarian follicle development
GO:0001819; positive regulation of cytokine production
GO:0001890; placenta development
GO:0001895; retina homeostasis
GO:0001975; response to amphetamine
GO:0002262; myeloid cell homeostasis
GO:0002576; platelet degranulation
GO:0006749; glutathione metabolic process

And 50 more GO terms

Cellular component:	GO:0005576; extracellular region GO:0005615; extracellular space GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005758; mitochondrial intermembrane space GO:0005759; mitochondrial matrix GO:0005764; lysosome GO:0005777; peroxisome GO:0005829; cytosol
	And 11 more GO terms

Function:

GO:0004784; superoxide dismutase activity
GO:0005507; copper ion binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0030346; protein phosphatase 2B binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0048365; Rac GTPase binding
GO:0051087; chaperone binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TXN, PIN1, BCL2, CAT, SOD2, SOD1, PRDX1, RGN, HSPA9, PCMT1, HSPA8, RAE1, STUB1, GPX4, TRAP1
STRING interaction network

Retrieve sequences for SOD1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: sod-5
Danio rerio: sod1
Drosophila melanogaster: Sod
Mus musculus: Sod1
Rattus norvegicus: Sod1
Saccharomyces cerevisiae: SOD1
Schizosaccharomyces pombe: sod1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
A homolog of this gene for Drosophila melanogaster is present as Sod

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1

LongevityMap

This gene is present as SOD1

CellAge

This gene is present as SOD1