GenAge entry for CAT (Homo sapiens)

Gene name (HAGRID: 107)

HGNC symbol: CAT
Aliases
Common name: catalase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. These mutants are also more resistant to age-related skeletal muscle dysfunction and exhibit improved voluntary exercise, increased muscle force, decreased intracellular Ca(2+) leak and increased sarcoplasmic reticulum Ca(2+) load [3638]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Cytogenetic information

Cytogenetic band: 11p13
Location: 34,438,925 bp to 34,472,060 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0001649; osteoblast differentiation
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0007568; aging
GO:0008203; cholesterol metabolic process
GO:0009060; aerobic respiration
GO:0009642; response to light intensity
GO:0009650; UV protection
GO:0010193; response to ozone
GO:0010288; response to lead ion
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823; response to activity
GO:0014854; response to inactivity
GO:0020027; hemoglobin metabolic process
GO:0032088; negative regulation of NF-kappaB transcription factor activity
GO:0032355; response to estradiol
GO:0032868; response to insulin
GO:0033189; response to vitamin A
GO:0033197; response to vitamin E
GO:0033591; response to L-ascorbic acid
GO:0042493; response to drug
GO:0042542; response to hydrogen peroxide
GO:0042744; hydrogen peroxide catabolic process
GO:0043066; negative regulation of apoptotic process
GO:0045471; response to ethanol
GO:0046686; response to cadmium ion
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051262; protein tetramerization
GO:0051289; protein homotetramerization
GO:0051781; positive regulation of cell division
GO:0055093; response to hyperoxia
GO:0070542; response to fatty acid
GO:0071363; cellular response to growth factor stimulus
GO:0080184; response to phenylpropanoid
GO:0098869; cellular oxidant detoxification

Cellular component:

GO:0005615; extracellular space
GO:0005739; mitochondrion
GO:0005758; mitochondrial intermembrane space
GO:0005764; lysosome
GO:0005777; peroxisome
GO:0005778; peroxisomal membrane
GO:0005782; peroxisomal matrix
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0016020; membrane
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome

Function:

GO:0004046; aminoacylase activity
GO:0004096; catalase activity
GO:0005102; receptor binding
GO:0016209; antioxidant activity
GO:0016684; oxidoreductase activity, acting on peroxide as acceptor
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050661; NADP binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PEX5, ABL1, CAT, SOD2, SOD1, APP, PRDX1, ESR1
STRING interaction network

Retrieve sequences for CAT

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ctl-3
Danio rerio: cat
Drosophila melanogaster: CG9314
Mus musculus: Cat
Rattus norvegicus: Cat
Saccharomyces cerevisiae: CTA1
Schizosaccharomyces pombe: cta1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Cat
A homolog of this gene for Saccharomyces cerevisiae is present as CTA1

LongevityMap

This gene is present as CAT