GenAge entry for EPOR (Homo sapiens)

Gene name (HAGRID: 52)

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Display region using the UCSC Genome Browser (GRCh38/hg38)

Gene Ontology

Process:

GO:0007165; signal transduction
GO:0007420; brain development
GO:0007507; heart development
GO:0046697; decidualization

Cellular component:

GO:0005576; extracellular region
GO:0005887; integral component of plasma membrane

Function:

GO:0004900; erythropoietin receptor activity
GO:0042802; identical protein binding

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Protein-protein interacting partners in GenAge: SHC1, PTPN11, STAT5A, IRS2, GRB2, PIK3R1, JAK2, SOCS2
STRING interaction network

CellAge