GenAge entry for FOXM1 (Homo sapiens)

Gene name (HAGRID: 131)

HGNC symbol: FOXM1
Aliases: HFH-11; trident; HNF-3; INS-1; MPP2; MPHOSPH2; TGT3; FKHL16
Common name: forkhead box M1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: A transcriptional regulator that is important in development, FOXM1 may also play a role in cell proliferation. In invertebrates, such as roundworms, the forkhead family has been linked to ageing [957]. In mice, FOXM1 has been associated with GH1-stimulated liver regeneration. Increased expression of FOXM1 in old mice restored hepatocyte proliferation to levels found in young animals [276]. It remains to be determined whether FOXM1 is involved in human ageing.

Cytogenetic information

Cytogenetic band: 12p13
Location: 2,857,681 bp to 2,877,155 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006281; DNA repair
GO:0006351; transcription, DNA-templated
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008284; positive regulation of cell proliferation
GO:0032873; negative regulation of stress-activated MAPK cascade
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046578; regulation of Ras protein signal transduction
GO:0051726; regulation of cell cycle
GO:0071156; regulation of cell cycle arrest
GO:0090344; negative regulation of cell aging
GO:2000377; regulation of reactive oxygen species metabolic process
GO:2000781; positive regulation of double-strand break repair

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm

Function:

GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0043565; sequence-specific DNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CREBBP, HSP90AA1, UBE2I, GSK3B, TERF1, RB1, SP1, CDK1, SUMO1, CTNNB1, CHEK2, GSK3A
STRING interaction network

Retrieve sequences for FOXM1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: foxm1
Mus musculus: Foxm1
Rattus norvegicus: Foxm1

In other databases

CellAge

This gene is present as FOXM1

CellAge gene expression

This gene is present as FOXM1