GenAge entry for GSK3B (Homo sapiens)

Gene name (HAGRID: 97)

HGNC symbol: GSK3B
Aliases
Common name: glycogen synthase kinase 3 beta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Involved in development and metabolism, GSK3B may also play a role in cell survival. GSK3B null mice die at embryonic stages [522]. Adult overexpression of GSK3B in the brain of mice resulted in neurodegeneration, suggesting GSK3B could be related to Alzheimer's disease [1682]. Its part in human ageing, if any, is unknown.

Cytogenetic information

Cytogenetic band: 3q13.3
Location: 119,821,955 bp to 120,094,417 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000320; re-entry into mitotic cell cycle
GO:0001837; epithelial to mesenchymal transition
GO:0001954; positive regulation of cell-matrix adhesion
GO:0005977; glycogen metabolic process
GO:0006349; regulation of gene expression by genetic imprinting
GO:0006468; protein phosphorylation
GO:0006611; protein export from nucleus
GO:0006983; ER overload response
GO:0007212; dopamine receptor signaling pathway
GO:0007409; axonogenesis
GO:0007520; myoblast fusion

And 54 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005813; centrosome GO:0005829; cytosol GO:0005886; plasma membrane GO:0014069; postsynaptic density GO:0030426; growth cone GO:0030529; intracellular ribonucleoprotein complex GO:0030877; beta-catenin destruction complex GO:0043025; neuronal cell body
	And 4 more GO terms

Function:	GO:0001085; RNA polymerase II transcription factor binding GO:0002020; protease binding GO:0002039; p53 binding GO:0004672; protein kinase activity GO:0004674; protein serine/threonine kinase activity GO:0005515; protein binding GO:0005524; ATP binding GO:0008013; beta-catenin binding GO:0016301; kinase activity GO:0019901; protein kinase binding GO:0031625; ubiquitin protein ligase binding
	And 4 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, E2F1, PTPN11, PTPN1, AKT1, MYC, HSP90AA1, TOP2A, NFKB1, CEBPB, STK11, GSK3B, PRKCA, PRKDC, AR, FEN1, FOXO1, FOXM1, APP, RELA, PTK2, JUN, EEF1A1, CREB1, MAPT, MDM2, MTOR, CTNNB1, PSEN1, PPP1CA, PPARGC1A, NFE2L2, RICTOR, NFE2L1
STRING interaction network

Retrieve sequences for GSK3B

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: gsk3b
Drosophila melanogaster: sgg
Mus musculus: Gsk3b
Rattus norvegicus: Gsk3b
Saccharomyces cerevisiae: MRK1

In other databases

CellAge

This gene is present as GSK3B