GenAge entry for NCOR2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 276)

HGNC symbol: NCOR2
Aliases: SMRT; SMRTE; TRAC-1; CTG26; TNRC14
Common name: nuclear receptor corepressor 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. Additionally, in a preliminary analysis, several human polymorphisms were found to be associated with type 2 diabetes [2196].

Cytogenetic information

Cytogenetic band: 12q24
Location: 124,324,411 bp to 124,567,464 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0044255; cellular lipid metabolic process
GO:0072365; regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA

Cellular component:

GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0016604; nuclear body
GO:0017053; transcriptional repressor complex

Function:

GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005112; Notch binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0042826; histone deacetylase binding
GO:0047485; protein N-terminus binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: E2F1, HDAC3, AKT1, NCOR1, FOS, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, AR, RELA, HDAC1, SP1, JUN, SIN3A, HDAC2, SUMO1, ESR1, NFKBIA, PPARG, NFE2L2, CDKN1A
STRING interaction network

Retrieve sequences for NCOR2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ncor2
Mus musculus: Ncor2
Rattus norvegicus: Ncor2

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ncor2