GenAge entry for PCK1 (Homo sapiens)

Gene name (HAGRID: 248)

HGNC symbol: PCK1
Aliases: PEPCK-C
Common name: phosphoenolpyruvate carboxykinase 1 (soluble)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: PCK1 is involved in the regulation of gluconeogenesis. Mice with PCK1 overexpressed in skeletal muscle were more active than controls and had an enhanced exercise capacity with an increased number of mitochondria. These mice ate more than controls, but had half the body weight and 10% the body fat. They were also reported to be long-lived [1839], though detailed ageing studies have not been conducted yet.

Cytogenetic information

Cytogenetic band: 20q13.31
Location: 57,561,081 bp to 57,566,457 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006006; glucose metabolic process
GO:0006094; gluconeogenesis
GO:0006107; oxaloacetate metabolic process
GO:0006475; internal protein amino acid acetylation
GO:0007568; aging
GO:0014823; response to activity
GO:0032496; response to lipopolysaccharide
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0042593; glucose homeostasis
GO:0046327; glycerol biosynthetic process from pyruvate
GO:0051365; cellular response to potassium ion starvation
GO:0061402; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
GO:0070741; response to interleukin-6
GO:0071300; cellular response to retinoic acid
GO:0071320; cellular response to cAMP
GO:0071332; cellular response to fructose stimulus
GO:0071347; cellular response to interleukin-1
GO:0071356; cellular response to tumor necrosis factor
GO:0071377; cellular response to glucagon stimulus
GO:0071456; cellular response to hypoxia
GO:1904640; response to methionine

Cellular component:

GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0070062; extracellular exosome

Function:

GO:0000287; magnesium ion binding
GO:0004613; phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525; GTP binding
GO:0019003; GDP binding
GO:0030145; manganese ion binding
GO:0031406; carboxylic acid binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EP300, APP, HSPD1, SQSTM1
STRING interaction network

Retrieve sequences for PCK1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: pck-1
Danio rerio: pck1
Drosophila melanogaster: CG10924
Mus musculus: Pck1
Rattus norvegicus: Pck1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Pck1

GenDR gene manipulations

A homolog of this gene for Mus musculus is present as Pck1