GenAge entry for PIK3CA (Homo sapiens)

Gene name (HAGRID: 286)

HGNC symbol: PIK3CA
Aliases: PI3K
Common name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing

Description

PIK3CA plays a role in activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. MTOR is a downstream effector of phosphoinositide 3-kinase, and thus PIK3CA might be also involved in ageing.

In mice, suppression of the activity of the p110alpha isoform of PIK3CA preserved cardiac function and prevented many age-associated changes in the heart [2227]. PIK3CA is also an oncogene and has been implicated in several types of cancers.

Cytogenetic information

Cytogenetic band: 3q26.3
Location: 179,148,523 bp to 179,234,709 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0001889; liver development
GO:0001944; vasculature development
GO:0006006; glucose metabolic process
GO:0006468; protein phosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0010468; regulation of gene expression
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016310; phosphorylation
GO:0030168; platelet activation
GO:0031295; T cell costimulation
GO:0032147; activation of protein kinase activity
GO:0033138; positive regulation of peptidyl-serine phosphorylation
GO:0036092; phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028; insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128; ERBB2 signaling pathway
GO:0040014; regulation of multicellular organism growth
GO:0043457; regulation of cellular respiration
GO:0043491; protein kinase B signaling
GO:0043524; negative regulation of neuron apoptotic process
GO:0043542; endothelial cell migration
GO:0044029; hypomethylation of CpG island
GO:0046854; phosphatidylinositol phosphorylation
GO:0048010; vascular endothelial growth factor receptor signaling pathway
GO:0048015; phosphatidylinositol-mediated signaling
GO:0050852; T cell receptor signaling pathway
GO:0050900; leukocyte migration
GO:0060048; cardiac muscle contraction
GO:0060612; adipose tissue development
GO:0071333; cellular response to glucose stimulus
GO:0097009; energy homeostasis
GO:2000270; negative regulation of fibroblast apoptotic process
GO:2000653; regulation of genetic imprinting
GO:2000811; negative regulation of anoikis

Cellular component:

GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0005943; phosphatidylinositol 3-kinase complex, class IA
GO:0030027; lamellipodium

Function:

GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0030295; protein kinase activator activity
GO:0035004; phosphatidylinositol 3-kinase activity
GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560; insulin receptor substrate binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IRS1, IRS2, AKT1, HRAS, GRB2, HDAC1, PIK3R1, ESR1, ATR, SQSTM1
STRING interaction network

Retrieve sequences for PIK3CA

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: LOC100334726
Mus musculus: Pik3ca
Rattus norvegicus: Pik3ca

In other databases

LongevityMap

This gene is present as PIK3CA

CellAge

This gene is present as PIK3CA